Atlas Protocol · Clinical Prevention

Atlas Thrombosis & Coagulation Module

28-gene thrombosis and coagulation panel for inherited bleeding and clotting disorders.


A 28-gene panel for inherited thrombophilias and coagulation disorders, including Factor V Leiden, Prothrombin G20210A, and protein C/S/antithrombin deficiencies.

GenDG §10

Bookable, after medical review.

Before the analysis, a specialist in human genetics reviews your preparation questionnaire and informs you (GenDG). If the test is declined, Atlas refunds the full amount.

HOW IT WORKS

How it works.

  1. 01

    Pay

    You pay Atlas for Atlas Baseline and the analysis.

  2. 02

    Questionnaire and physician review

    You receive a questionnaire by email from the physician's practice, and a specialist in human genetics reviews it. If the test is declined, you get a full automatic refund.

  3. 03

    Counselling slot

    You choose a counselling slot or join the waitlist.

  4. 04

    Consent, kit and result

    After the counselling you give your consent, then we ship your collection kit. The physician discusses the result with you.

WHICH PART OF YOUR BODY

Which part of your body.

  • Blood clotting
  • Lungs (pulmonary embolism)
  • Legs (deep vein thrombosis)
  • Brain (stroke)
WHAT THIS PANEL ANSWERS

What this panel answers.

Do you carry inherited variants that raise your risk of forming dangerous blood clots?

WHAT CHANGES IF A FINDING IS IDENTIFIED

What changes if something is found.

  1. Factor V Leiden, prothrombin, protein C and S deficiency, and antithrombin deficiency carriers receive concrete travel and surgical precautions -- compression stockings on long-haul flights, prophylactic anticoagulation around major surgery, hospitalization, and pregnancy.
  2. Hormonal contraception and hormone-replacement decisions are individualized with your physician.
  3. Family cascade testing identifies relatives at the same risk.
Pathway references
  • GenDG §7
GENES ANALYZED

What is analyzed.

Atlas analyzes each gene in its entirety -- not just hotspot regions -- against current clinical literature. Findings are assessed by a specialist in human genetics before release.

Thrombosis & Coagulation Disorders

28 genes

A 28-gene panel covering inherited clotting and bleeding disorders. Includes the common thrombophilia variants (Factor V Leiden in F5, prothrombin in F2), the protein C/S/antithrombin pathway, von Willebrand factor, and the hemophilia A/B factor genes.

Clinical areas covered
  • Factor V Leiden and prothrombin variants
  • Protein C / protein S deficiency
  • Antithrombin deficiency
  • Von Willebrand disease
  • Hemophilia A and B
  • Platelet-function disorders
Analyzed genes -- 28 genes
  • ADAMTS13
  • F10
  • F11
  • F12
  • F13A1
  • F13B
  • F2
  • F5
  • F7
  • F8
  • F9
  • GFI1B
  • GP1BA
  • GP1BB
  • GP6
  • GP9
  • HRG
  • ITGA2B
  • ITGB3
  • LMAN1
  • MCFD2
  • NBEAL2
  • PROC
  • PROS1
  • SERPINC1
  • SERPIND1
  • SERPINF2
  • VWF
Limitations
  • F8 intronic inversions are not detected by the standard short-read sequencing assay -- if hemophilia A is clinically suspected, an inversion-specific test is required.

Gene list version 2026-05.

WHY THIS MATTERS

Why early knowledge matters.

  • Thrombosis & Coagulation Disorders

    Inherited thrombophilia substantially raises the risk of deep-vein thrombosis, pulmonary embolism, and stroke -- particularly under hormonal contraception, pregnancy, surgery, immobilization, or long-haul travel. Knowing your status can change which contraceptive a physician prescribes and what perioperative prophylaxis is used.

RESULT INTERPRETATION

How findings are reported.

Every Atlas predictive report uses the same five-outcome framework so you and your physician can read it the same way each time.

  1. 01

    Pathogenic variant

    Increased disease risk. The report includes an individualized prevention plan and a recommendation to discuss next steps with a physician or medical geneticist.

  2. 02

    Likely pathogenic variant

    Probable disease association. Preventive monitoring is typically justified; the strength of evidence is documented in the report.

  3. 03

    Variant of uncertain significance (VUS)

    Reported but not currently actionable. A VUS may be reclassified over time as new evidence accumulates -- Atlas does not act on VUS findings without specialist review.

  4. 04

    No relevant variant in this panel

    No pathogenic or likely-pathogenic variant was identified in the analyzed genes. This does not eliminate all genetic risk -- only the genes in this panel were assessed.

  5. 05

    Family implications

    When an actionable variant is found, cascade testing of first-degree relatives is typically recommended -- a decision made together with a counselor.

Module-specific implications
  • Thrombosis & Coagulation Disorders

    • A confirmed thrombophilia variant is typically discussed with a hematologist or human geneticist -- not all carriers need anticoagulation, and decisions are context-specific.
    • Pregnancy, surgery, and hormonal therapy are common triggers where the finding changes management.
    • Bleeding-disorder findings (VWF, F8, F9) inform safe surgical, dental, and obstetric care.
Counseling and cascade testing

Predictive genetic testing in Germany requires consultation with a physician qualified in human genetics under §7 of the GenDG (Arztvorbehalt). This counseling, before and after the test, is given by a specialist in human genetics. When an actionable finding has implications for relatives, this physician discusses cascade testing with you, not Atlas alone.

CLINICAL LIMITATIONS

What this test does not do.

  • Not a diagnosis of active disease

    A variant indicates predisposition. It does not confirm a condition is currently present.

  • Does not replace screening or routine care

    Imaging, lab work, and physical examination remain part of clinical care. Atlas results inform them; they do not substitute for them.

  • Not all risk is genetic

    Environment, behavior, age, and chance contribute to most common conditions. A genetic test reads one input.

  • A negative result does not eliminate risk

    Only the genes on the panel were analyzed. Variants in other genes, in non-coding regions, and outside the assay's technical scope are not assessed.

  • Clinical decisions remain with your physician

    Atlas reports are designed to be reviewed with a physician or medical geneticist. We do not recommend acting on a finding without that conversation.

GenDG §7

Predictive panels on this page are GenDG §7 Arztvorbehalt: counseling with a qualified human-genetics physician is required before and after the test. This counseling is given by a specialist in human genetics.


Ready to start?

Book →

Not sure if this is the right protocol? Let Atlas walk you through a few questions. Start Triage →

Or browse all 24 protocols: Open the Console →

Not ready? Book a counseling session first →

Already have your genome with Atlas?

See Atlas Baseline