Atlas Protocol · Clinical Prevention

Atlas Familial Diabetes Module

8-gene panel for monogenic diabetes (MODY) and other inherited diabetes forms.

An 8-gene panel for monogenic forms of diabetes (MODY) and related inherited diabetes — distinguishing from polygenic Type 2 risk.

GenDG §10

Bookable, after medical review.

Before the analysis, a specialist in human genetics reviews your preparation questionnaire and informs you (GenDG). If the test is declined, Atlas refunds the full amount.

HOW IT WORKS

How it works.

  1. 01

    Pay

    You pay Atlas for Atlas Baseline and the analysis.

  2. 02

    Questionnaire and physician review

    You receive a questionnaire by email from the physician's practice, and a specialist in human genetics reviews it. If the test is declined, you get a full automatic refund.

  3. 03

    Counselling slot

    You choose a counselling slot or join the waitlist.

  4. 04

    Consent, kit and result

    After the counselling you give your consent, then we ship your collection kit. The physician discusses the result with you.

WHICH PART OF YOUR BODY

Which part of your body.

  • Pancreas
  • Metabolism
WHAT THIS PANEL ANSWERS

What this panel answers.

Do you carry an inherited variant that causes a specific genetic form of diabetes often misdiagnosed as type 1 or type 2?

WHAT CHANGES IF A FINDING IS IDENTIFIED

What changes if something is found.

  1. MODY-HNF1A responds well to oral sulfonylureas and often does not require insulin.
  2. MODY-GCK is a stable, mild hyperglycemia that requires no treatment in most cases.
  3. A correct molecular diagnosis avoids unnecessary insulin therapy and informs family screening.
  4. The diagnosis often changes pregnancy management and reproductive planning.
Pathway references
  • GenDG §7
GENES ANALYZED

What is analyzed.

Atlas analyzes each gene in its entirety -- not just hotspot regions -- against current clinical literature. Findings are assessed by a specialist in human genetics before release.

Familial Diabetes

8 genes

An 8-gene panel for monogenic forms of diabetes. MODY is frequently misdiagnosed as Type 1 or Type 2 diabetes -- the correct molecular diagnosis can change treatment substantially. MODY-HNF1A responds to oral sulfonylureas (often replacing insulin), MODY-GCK typically requires no treatment, and HNF1B carries kidney as well as pancreatic features.

Clinical areas covered
  • MODY (Maturity-Onset Diabetes of the Young), subtypes 1-6+
  • Neonatal diabetes (selected genes)
Analyzed genes -- 8 genes
  • ABCC8
  • GCK
  • HNF1A
  • HNF1B
  • HNF4A
  • INS
  • KCNJ11
  • PDX1

Gene list version 2026-05.

WHY THIS MATTERS

Why early knowledge matters.

  • Familial Diabetes

    Familial diabetes can develop quietly over years before symptoms appear. A correct genetic diagnosis can replace inappropriate insulin therapy with an oral agent (or no treatment), inform family screening, and guide pregnancy care.

RESULT INTERPRETATION

How findings are reported.

Every Atlas predictive report uses the same five-outcome framework so you and your physician can read it the same way each time.

  1. 01

    Pathogenic variant

    Increased disease risk. The report includes an individualized prevention plan and a recommendation to discuss next steps with a physician or medical geneticist.

  2. 02

    Likely pathogenic variant

    Probable disease association. Preventive monitoring is typically justified; the strength of evidence is documented in the report.

  3. 03

    Variant of uncertain significance (VUS)

    Reported but not currently actionable. A VUS may be reclassified over time as new evidence accumulates -- Atlas does not act on VUS findings without specialist review.

  4. 04

    No relevant variant in this panel

    No pathogenic or likely-pathogenic variant was identified in the analyzed genes. This does not eliminate all genetic risk -- only the genes in this panel were assessed.

  5. 05

    Family implications

    When an actionable variant is found, cascade testing of first-degree relatives is typically recommended -- a decision made together with a counselor.

Module-specific implications

  • Familial Diabetes

    • A MODY finding is typically reviewed with an endocrinologist to revisit current treatment.
    • Cascade testing is informative -- MODY is autosomal dominant, so each first-degree relative has a 50% chance of carrying the same variant.
Counseling and cascade testing

Predictive genetic testing in Germany requires consultation with a physician qualified in human genetics under §7 of the GenDG (Arztvorbehalt). This counseling, before and after the test, is given by a specialist in human genetics. When an actionable finding has implications for relatives, this physician discusses cascade testing with you, not Atlas alone.

CLINICAL LIMITATIONS

What this test does not do.

  • Not a diagnosis of active disease

    A variant indicates predisposition. It does not confirm a condition is currently present.

  • Does not replace screening or routine care

    Imaging, lab work, and physical examination remain part of clinical care. Atlas results inform them; they do not substitute for them.

  • Not all risk is genetic

    Environment, behavior, age, and chance contribute to most common conditions. A genetic test reads one input.

  • A negative result does not eliminate risk

    Only the genes on the panel were analyzed. Variants in other genes, in non-coding regions, and outside the assay's technical scope are not assessed.

  • Clinical decisions remain with your physician

    Atlas reports are designed to be reviewed with a physician or medical geneticist. We do not recommend acting on a finding without that conversation.

GenDG §7

Predictive panels on this page are GenDG §7 Arztvorbehalt: counseling with a qualified human-genetics physician is required before and after the test. This counseling is given by a specialist in human genetics.

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